Experimental Relocation of the Mitochondrial ATP9 Gene to the Nucleus Reveals Forces Underlying Mitochondrial Genome Evolution

@inproceedings{Bietenhader2012ExperimentalRO,
  title={Experimental Relocation of the Mitochondrial ATP9 Gene to the Nucleus Reveals Forces Underlying Mitochondrial Genome Evolution},
  author={Ma{\"i}lis Bietenhader and Alexandre Martos and Emmanuel T{\'e}taud and Raeka S Aiyar and Carole H. Sellem and Roza Kucharczyk and Sandra Clauder-Muenster and M Kathryn Giraud and François Godard and B{\'e}n{\'e}dicte Salin and Isabelle Sagot and Julien Gagneur and Michelle D{\'e}quard-Chablat and V{\'e}ronique Contamine and Sylvie Hermann-Le Denmat and Annie Sainsard-Chanet and Lars M. Steinmetz and Jean-Paul di Rago},
  booktitle={PLoS genetics},
  year={2012}
}
Only a few genes remain in the mitochondrial genome retained by every eukaryotic organism that carry out essential functions and are implicated in severe diseases. Experimentally relocating these few genes to the nucleus therefore has both therapeutic and evolutionary implications. Numerous unproductive attempts have been made to do so, with a total of only… CONTINUE READING