Experimental Pyelonephritis. X. Direct Injection of E. Coli Protoplasts into the Medulla of the Rabbit Kidney †

@article{Alderman1963ExperimentalPX,
  title={Experimental Pyelonephritis. X. Direct Injection of E. Coli Protoplasts into the Medulla of the Rabbit Kidney †},
  author={Michael H. Alderman and Lawrence R. Freedman},
  journal={The Yale Journal of Biology and Medicine},
  year={1963},
  volume={36},
  pages={157 - 164}
}
Previous studies have demonstrated that the renal medulla is more susceptible to bacterial infection than the cortex.' Although more than 100,000 organisms are usually required to produce infection when injected directly into the normal renal cortex, fewer than 10 are necessary in the medulla. Many factors contribute to the remarkable ease with which infection is initiated in the renal medulla. Among these are the anti-complementary effect of ammonia2" and the interference with phagocytosis… CONTINUE READING