Experimental Limitations Using Reprogrammed Cells for Hematopoietic Differentiation

@inproceedings{Seiler2011ExperimentalLU,
  title={Experimental Limitations Using Reprogrammed Cells for Hematopoietic Differentiation},
  author={K. Stephen Seiler and Motokazu Tsuneto and Fritz Georg Melchers},
  booktitle={Journal of biomedicine & biotechnology},
  year={2011}
}
We review here our experiences with the in vitro reprogramming of somatic cells to induced pluripotent stem cells (iPSC) and subsequent in vitro development of hematopoietic cells from these iPSC and from embryonic stem cells (ESC). While, in principle, the in vitro reprogramming and subsequent differentiation can generate hematopoietic cell from any somatic cells, it is evident that many of the steps in this process need to be significantly improved before it can be applied to human cells and… CONTINUE READING
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