Experimental HBV and δ infections of chimpanzees: Occurrence and significance of intrahepatic immune complexes of HBcAg and δ antigen

@article{Rizzetto1981ExperimentalHA,
  title={Experimental HBV and $\delta$ infections of chimpanzees: Occurrence and significance of intrahepatic immune complexes of HBcAg and $\delta$ antigen},
  author={Mario Rizzetto and Maria G. Canese and Robert H. Purcell and William T. London and L. David Sly and John L. Gerin},
  journal={Hepatology},
  year={1981},
  volume={1}
}
The occurrence and pathogenetic role of intrahepatic deposits of immunoglobulins in experimental viral infection have been evaluated by determining with immunofluorescence their capacity to fix complement in vitro [in vitro complement fixation (VCF)]. Liver biopsies from chimpanzees chronically or acutely infected with hepatitis B virus or the hepatitis B surface antigen (HBsAg)‐associated δ agent were used in the study. VCF was observed in each animal expressing hepatitis B core antigen (HBcAg… 
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