Experimental H-type bovine spongiform encephalopathy characterized by plaques and glial- and stellate-type prion protein deposits

@inproceedings{Okada2011ExperimentalHB,
  title={Experimental H-type bovine spongiform encephalopathy characterized by plaques and glial- and stellate-type prion protein deposits},
  author={Hiroyuki Okada and Yoshifumi Iwamaru and Morikazu Imamura and Kentaro Masujin and Yuichi Matsuura and Yoshihisa Shimizu and Kazuo Kasai and Shirou Mohri and Takashi Yokoyama and Stefanie Czub},
  booktitle={Veterinary research},
  year={2011}
}
Atypical bovine spongiform encephalopathy (BSE) has recently been identified in Europe, North America, and Japan. It is classified as H-type and L-type BSE according to the molecular mass of the disease-associated prion protein (Pr(PSc)). To investigate the topographical distribution and deposition patterns of immunolabeled Pr(PSc), H-type BSE isolate was inoculated intracerebrally into cattle. H-type BSE was successfully transmitted to 3 calves, with incubation periods between 500 and 600 days… CONTINUE READING