Experimental Glaucoma Induced by Ocular Injection of Magnetic Microspheres

  title={Experimental Glaucoma Induced by Ocular Injection of Magnetic Microspheres},
  author={Shannon Bunker and Joanna Holeniewska and Sauparnika Vijay and Annegret Hella Dahlmann-Noor and Peng T. Khaw and Yin Shan Eric Ng and David T. Shima and Richard H. Foxton},
  booktitle={Journal of visualized experiments : JoVE},
Progress in understanding the pathophysiology, and providing novel treatments for glaucoma is dependent on good animal models of the disease. We present here a protocol for elevating intraocular pressure (IOP) in the rat, by injecting magnetic microspheres into the anterior chamber of the eye. The use of magnetic particles allows the user to manipulate the beads into the iridocorneal angle, thus providing a very effective blockade of fluid outflow from the trabecular meshwork. This leads to… CONTINUE READING
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