Experimental Cannabinoid 2 Receptor Inhibition in CNS Injury‐Induced Immunodeficiency Syndrome

  title={Experimental Cannabinoid 2 Receptor Inhibition in CNS Injury‐Induced Immunodeficiency Syndrome},
  author={I. Burkovskiy and J. Zhou and C. Lehmann},
  pages={283 - 292}
Severe CNS injury, such as stroke, traumatic brain injury, or spinal cord injury, is known to increase susceptibility to infections. The increased susceptibility to infection is due to an impaired immune response and is referred to as CIDS. The CB2 receptor on immune cells presents a potential therapeutic target in CIDS as activation of this receptor has been shown to be involved in immunosuppression. The main purpose of this study was to determine the impact of CB2 receptor inhibition on… Expand
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Understanding CIDS will allow us to work on developing effective therapeutic strategies, with which the outcome after CNS damage by a host of diseases could be improved by eliminating a major determinant of poor recovery. Expand
Central nervous system injury-induced immune deficiency syndrome
Understanding CIDS will allow us to work on developing effective therapeutic strategies, with which the outcome after CNS damage by a host of diseases could be improved by eliminating a major determinant of poor recovery. Expand
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Clinical evidence is emerging demonstrating that stroke-induced immunodepression in humans not only exists, but has very similar features to those characterized in rodent experiments. Expand
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A concept that links the peripheral immune suppression with the development of local inflammation is proposed, which is effective in reducing infection and improving clinical outcome in experimental stroke and appears causally related to stroke‐induced immune suppression. Expand
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