Experimental BPA Exposure and Glucose-Stimulated Insulin Response in Adult Men and Women

@article{Stahlhut2018ExperimentalBE,
  title={Experimental BPA Exposure and Glucose-Stimulated Insulin Response in Adult Men and Women},
  author={Richard W. Stahlhut and John Peterson Myers and Julia A. Taylor and Angel Nadal and Jonathan A Dyer and Frederick S vom Saal},
  journal={Journal of the Endocrine Society},
  year={2018},
  volume={2},
  pages={1173 - 1187}
}
Abstract Context Human cross-sectional and animal studies have shown an association of the chemical bisphenol A (BPA) with insulin resistance, type 2 diabetes, and other metabolic diseases, but no human experimental study has investigated whether BPA alters insulin/C-peptide secretion. Design Men and postmenopausal women (without diabetes) were orally administered either the vehicle or a BPA dose of 50 µg/kg body weight, which has been predicted by US regulators (Food and Drug Administration… 

Figures and Tables from this paper

Pilot Study on the Effect of Orally Administered Bisphenol A on Glucose and Insulin Response in Nonobese Adults

Orally administered BPA protocol appeared feasible and has immediate effects on glucose, insulin, and C-peptide concentrations.

Bisphenol A and Type 2 Diabetes Mellitus: A Review of Epidemiologic, Functional, and Early Life Factors

Type 2 diabetes mellitus (T2DM) is characterised by insulin resistance and eventual pancreatic β-cell dysfunction, resulting in persistent high blood glucose levels, and BPA is a pervasive EDC, being the main constituent of polycarbonate plastics.

Exposure to low doses of Dechlorane Plus promotes adipose tissue dysfunction and glucose intolerance in male mice.

Exposure of mice to low, environmentally relevant doses of Dechlorane Plus (DP), promoted glucose intolerance in mice fed high fat diet independent of weight gain and had pronounced effects on the adipose tissue.

Exposure to Endocrine-Disrupting Chemicals and Type 2 Diabetes Mellitus in Later Life

This review summarizes the most recent advances in this field, including diabetes-related EDCs, EDC exposure and gestational diabetes mellitus, prenatal and perinatal EDC exposures and T2DM, adult EDC Exposure and T1DM, transgenerational effects of EDCs on T2 DM as well as the possible diabetogenic mechanisms.

Exposure to Bisphenol a Substitutes and Gestational Diabetes Mellitus: A Prospective Cohort Study in China

Evidence is provided that BPAF and BPS might be potential risk factors of GDM, which require to be studied further.

References

SHOWING 1-10 OF 49 REFERENCES

The Estrogenic Effect of Bisphenol A Disrupts Pancreatic β-Cell Function In Vivo and Induces Insulin Resistance

The results in this article show that the widespread environmental contaminant bisphenol-A (BPA) imitates 17β-estradiol (E2) effects in vivo on blood glucose homeostasis through genomic and nongenomic pathways.

Urinary Bisphenol A and Hypertension in a Multiethnic Sample of US Adults

Urinary BPA levels are associated with hypertension, independent of traditional risk factors, and the association was consistently present in subgroup analyses by race/ethnicity, smoking status, BMI, and diabetes mellitus.

Rapid Insulinotropic Action of Low Doses of Bisphenol-A on Mouse and Human Islets of Langerhans: Role of Estrogen Receptor β

BPA behaves as a strong estrogen via nuclear ERβ and results obtained with BPA in mouse β-cells may be extrapolated to humans, suggesting that BPA should be considered as a risk factor for metabolic disorders in humans.

Endocrine disruptors in the etiology of type 2 diabetes mellitus

Evidence already exists to consider exposure to endocrine disrupting chemicals as a risk factor in the etiology of type 2 diabetes mellitus and other diseases related to insulin resistance, and more experimental work is necessary.

Urinary Bisphenol A Concentration and Risk of Future Coronary Artery Disease in Apparently Healthy Men and Women

Background— The endocrine-disrupting chemical bisphenol A (BPA) is widely used in food and beverage packaging. Higher urinary BPA concentrations were cross-sectionally associated with heart disease

Initial hyperinsulinemia and subsequent β-cell dysfunction is associated with elevated palmitate levels

The rapid accentuated and delayed insulin secretory responses observed in obese children and adolescents, respectively, with high palmitate levels may reflect changes in islet secretory activity and integrity induced by extended exposure to the fatty acid.

Association of urinary bisphenol A concentration with medical disorders and laboratory abnormalities in adults.

Higher BPA exposure, reflected in higher urinary concentrations of BPA, may be associated with avoidable morbidity in the community-dwelling adult population.

Association between urinary bisphenol A concentration and obesity prevalence in children and adolescents.

Urinary BPA concentration was significantly associated with obesity in this cross-sectional study of children and adolescents and could not rule out the possibility that obese children ingest food with higher BPA content or have greater adipose stores of BPA.

Oestrogens and insulin secretion

Evidence from clinical trials suggesting that women on postmenopausal oestrogen hormone replacement therapy (HRT) have a reduced incidence of type 2 diabetes appears paradoxical, but the mechanism responsible for this benefit merits further investigation and might lead to new therapies.