AIM The purpose of this study was to explore and describe the experiences of Iranian infertile women regarding infertility. METHODS A qualitative design, based on a content analysis approach, was used to reach this study aim. After employing purposive sampling to choose 10 women who were seeking infertility treatment at a referral center in Tehran, Iran, semi-structured interviews were carried out to gather data. RESULTS During the data analysis, four main themes emerged including "abuse", "marital instability", "social isolation", and "loss of self- esteem". CONCLUSION Infertility influences both the psychological and social well-being of women. Improving the knowledge of healthcare professionals especially nurses about the complications of infertility and its related cultural-contextual factors are crucial in order to provide high quality care to infertile women.