Experience with anti-TNF-α therapy for orofacial granulomatosis.

  title={Experience with anti-TNF-α therapy for orofacial granulomatosis.},
  author={Tim R Elliott and Helen Campbell and M. P. Escudier and T W J Poate and Carlo Nunes and M C E Lomer and A Lexi Mentzer and Pritash Patel and Penelope J Shirlaw and Jonathon Brostoff and Stephen J Challacombe and Jeremy David Sanderson},
  journal={Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology},
  volume={40 1},
BACKGROUND Orofacial granulomatosis (OFG) can be challenging to treat and experience with anti-TNF-α therapy is limited. We report our experience with infliximab (IFX) and adalimumab (ADA) for OFG in 14 patients, the largest reported series to date. METHODS A review of patients receiving induction and maintenance IFX for OFG +/- Crohn's disease (CD) for active oral disease failing other therapies was performed. Clinical response defined by global physician assessment, aided by oral disease… CONTINUE READING

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