Experience with a once-daily aminoglycoside program administered to 2,184 adult patients.

@article{Nicolau1995ExperienceWA,
  title={Experience with a once-daily aminoglycoside program administered to 2,184 adult patients.},
  author={David P Nicolau and C. Daniel Freeman and Paul Belliveau and Charles H. Nightingale and Jack W. Ross and Richard Quintiliani},
  journal={Antimicrobial agents and chemotherapy},
  year={1995},
  volume={39 3},
  pages={650-5}
}
Once-daily aminoglycoside (ODA) regimens have been instituted to maximize bacterial killing by optimizing the peak concentration/MIC ratio and to reduce the potential for toxicity. We initiated an ODA program at our institution that utilizes a fixed 7-mg/kg intravenous dose with a drug administration interval based on estimated creatinine clearance: > or = 60 ml/min every 24 h (q24h), 59 to 40 ml/min q36h, and 39 to 20 ml/min q48h. Subsequent interval adjustments are made by using a single… CONTINUE READING
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