Experience with a mouse intranasal test for the predictive identification of respiratory sensitization potential of proteins.

@article{Blaikie1999ExperienceWA,
  title={Experience with a mouse intranasal test for the predictive identification of respiratory sensitization potential of proteins.},
  author={L Blaikie and David A Basketter},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  year={1999},
  volume={37 8},
  pages={889-96}
}
The predictive identification of respiratory allergenic potential is an important primary step in the safety evaluation of (novel) proteins, such as the enzymes used in a range of consumer laundry products. In the past this has been achieved by assessing the relative ability of proteins to give rise to the formation of anaphylactic antibody in the guinea pig. Recently, an alternative model has been proposed which assesses the formation of specific IgG1 antibody in a mouse intranasal test (MINT… CONTINUE READING