Experience with Cyproterone Acetate in the Treatment of Precocious Puberty

  title={Experience with Cyproterone Acetate in the Treatment of Precocious Puberty},
  author={Z. Laron and R. Kauli},
  journal={Journal of Pediatric Endocrinology and Metabolism},
  pages={805 - 810}
  • Z. Laron, R. Kauli
  • Published 2000
  • Medicine
  • Journal of Pediatric Endocrinology and Metabolism
  • The authors review their experience (1967-present) in the use of cyproterone acetate (CPA) in precocious puberty. CPA was found effective in persistently suppressing pituitary gonadotropic secretion when administered orally at a dose of 50 mg b.i.d. (70-100 mg/d). After the introduction of gonadotropic analogues (GnRHa) for treatment of central precocious puberty, short term use of CPA was found useful to counteract the initial stimulatory effect of the GnRHa as well as an adjunct drug in case… CONTINUE READING
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