Experience-dependent structural synaptic plasticity in the mammalian brain

@article{Holtmaat2009ExperiencedependentSS,
  title={Experience-dependent structural synaptic plasticity in the mammalian brain},
  author={A. Holtmaat and K. Svoboda},
  journal={Nature Reviews Neuroscience},
  year={2009},
  volume={10},
  pages={647-658}
}
Synaptic plasticity in adult neural circuits may involve the strengthening or weakening of existing synapses as well as structural plasticity, including synapse formation and elimination. Indeed, long-term in vivo imaging studies are beginning to reveal the structural dynamics of neocortical neurons in the normal and injured adult brain. Although the overall cell-specific morphology of axons and dendrites, as well as of a subpopulation of small synaptic structures, are remarkably stable, there… Expand
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References

SHOWING 1-10 OF 233 REFERENCES
Long-term in vivo imaging of experience-dependent synaptic plasticity in adult cortex
TLDR
The measurements suggest that sensory experience drives the formation and elimination of synapses and that these changes might underlie adaptive remodelling of neural circuits. Expand
Anatomical and physiological plasticity of dendritic spines.
TLDR
This work reviews recent studies demonstrating in vivo that spines are motile and plastic structures whose morphology and lifespan are influenced, even in adult animals, by changes in sensory input, and suggests morphological changes are not required for all forms of synaptic plasticity. Expand
Remodeling of Synaptic Structure in Sensory Cortical Areas In Vivo
TLDR
The data suggest that changes in network function during adult learning and memory might occur through changes in the strength and efficacy of existing synapses as well as some remodeling of connectivity through the loss and gain of synapses. Expand
Formation of Dendritic Spines with GABAergic Synapses Induced by Whisker Stimulation in Adult Mice
TLDR
Activity-dependent alterations in synaptic circuitry in adulthood are indicated, modifying the flow of sensory information into the cerebral cortex in adulthood. Expand
Bidirectional Activity-Dependent Morphological Plasticity in Hippocampal Neurons
TLDR
The data show that hippocampal neurons can undergo bidirectional morphological plasticity; spines are formed and eliminated in an activity-dependent way and the ability of neurons to eliminate spines in anActivity-dependent manner decreased with developmental age. Expand
Dynamic Remodeling of Dendritic Arbors in GABAergic Interneurons of Adult Visual Cortex
TLDR
The first unambiguous evidence (to the authors' knowledge) of dendrite growth and remodeling in adult neurons is shown and it is suggested that circuit rearrangement in the adult cortex is restricted by cell type–specific rules. Expand
Imaging of experience-dependent structural plasticity in the mouse neocortex in vivo
TLDR
Data indicate that novel sensory experience drives the stabilization of new spines on subclasses of cortical neurons and promotes the formation of new synapses, which likely underlie experience-dependent functional remodeling of specific neocortical circuits. Expand
Dendritic spine changes associated with hippocampal long-term synaptic plasticity
TLDR
After induction of long-lasting (but not short-lasting) functional enhancement of synapses in area CA1, new spines appear on the postsynaptic dendrite, whereas in control regions on the same dendrites or in slices where long-term potentiation was blocked, no significant spine growth occurred. Expand
Synapse formation on neurons born in the adult hippocampus
TLDR
It is reported that new neurons born in the adult mouse hippocampus were contacted by axosomatic, axodendritic and axospinous synapses, and dendritic spines primarily synapsed on multiple-synapse boutons, suggesting that initial contacts were preferentially made with preexisting boutons already involved in a synapse. Expand
Actin-based plasticity in dendritic spines.
TLDR
New developments in light microscopy allow changes in spine morphology to be directly visualized in living neurons and suggest that a common mechanism, based on dynamic actin filaments, is involved in both the formation of dendritic spines during development and their structural plasticity at mature synapses. Expand
...
1
2
3
4
5
...