Experience-dependent structural synaptic plasticity in the mammalian brain

  title={Experience-dependent structural synaptic plasticity in the mammalian brain},
  author={Anthony Holtmaat and K. Svoboda},
  journal={Nature Reviews Neuroscience},
  • Anthony Holtmaat, K. Svoboda
  • Published 2009
  • Biology, Medicine
  • Nature Reviews Neuroscience
  • Synaptic plasticity in adult neural circuits may involve the strengthening or weakening of existing synapses as well as structural plasticity, including synapse formation and elimination. Indeed, long-term in vivo imaging studies are beginning to reveal the structural dynamics of neocortical neurons in the normal and injured adult brain. Although the overall cell-specific morphology of axons and dendrites, as well as of a subpopulation of small synaptic structures, are remarkably stable, there… CONTINUE READING
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