Experience-dependent regulation of CaMKII activity within single visual cortex synapses in vivo.

@article{Mower2011ExperiencedependentRO,
  title={Experience-dependent regulation of CaMKII activity within single visual cortex synapses in vivo.},
  author={Amanda F Mower and Showming Kwok and Hongbo Yu and Ania K Majewska and Ken-ichi Okamoto and Yasunori Hayashi and Mriganka Sur},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2011},
  volume={108 52},
  pages={21241-6}
}
Unbalanced visual input during development induces persistent alterations in the function and structure of visual cortical neurons. The molecular mechanisms that drive activity-dependent changes await direct visualization of underlying signals at individual synapses in vivo. By using a genetically engineered Förster resonance energy transfer (FRET) probe for the detection of CaMKII activity, and two-photon imaging of single synapses within identified functional domains, we have revealed… CONTINUE READING

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