Experience-dependent changes in NMDA receptor composition at mature central synapses.

  title={Experience-dependent changes in NMDA receptor composition at mature central synapses.},
  author={Caroline Kopp and Fabio Longordo and Anita L{\"u}thi},
  volume={53 1},
N-methyl-D-aspartate receptor (NMDAR) activation is obligatory for the induction of diverse forms of synaptic plasticity. The molecular composition and the function of NMDARs are themselves modified by synaptic activity, which, in turn, alters the ability of synapses to undergo subsequent plastic modification. This homeostatic control of synaptic plasticity is well-known for the experience-dependent development of sensory cortices. However, it is now becoming clear that NMDAR properties may not… CONTINUE READING


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