Expedient total synthesis of pyrrothine natural products and analogs.

  title={Expedient total synthesis of pyrrothine natural products and analogs.},
  author={Thomas Hjelmgaard and Michael C Givskov and John Rauhe Nielsen},
  journal={Organic & biomolecular chemistry},
  volume={5 2},
This paper describes an expedient and straightforward total synthesis of the two pyrrothine natural products holomycin (7 steps, 11% overall) and xenorhabdin I (7 steps, 11% overall) and analogs thereof via a common late-stage intermediate. The pathway proceeds via the pyrrothine hydrochloride intermediate (6 steps, 17% overall) which also gave access to very fast synthesis of analogs as demonstrated by the synthesis of , and (7 steps, 11-12% overall). 

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