Expedient Iron-Catalyzed C-H Allylation/Alkylation by Triazole Assistance with Ample Scope.

Abstract

Triazole assistance set the stage for a unified strategy for the iron-catalyzed C-H allylation of arenes, heteroarenes, and alkenes with ample scope. The versatile catalyst also proved competent for site-selective methylation, benzylation, and alkylation with challenging primary and secondary halides. Triazole-assisted C-H activation proceeded chemo-, site-, and diastereo-selectively, and the modular TAM directing group was readily removed in a traceless fashion under exceedingly mild reaction conditions.

DOI: 10.1002/anie.201509603

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Cite this paper

@article{Cera2016ExpedientIC, title={Expedient Iron-Catalyzed C-H Allylation/Alkylation by Triazole Assistance with Ample Scope.}, author={Gianpiero Cera and Tobias Haven and Lutz Ackermann}, journal={Angewandte Chemie}, year={2016}, volume={55 4}, pages={1484-8} }