Expansions, diversification, and interindividual copy number variations of AID/APOBEC family cytidine deaminase genes in lampreys

  title={Expansions, diversification, and interindividual copy number variations of AID/APOBEC family cytidine deaminase genes in lampreys},
  author={Stephen J Holland and Lesley M. Berghuis and Justin J King and Lakshminarayan M. Iyer and Katarzyna Sikora and Heather Fifield and Sarah Peter and Emma M. Quinlan and Fumiaki Sugahara and Prashant Shingate and In{\^e}s Trancoso and Norimasa Iwanami and Elena N. Temereva and C M Strohmeier and Shigeru Kuratani and Byrappa Venkatesh and Guillaume Evanno and L. Aravind and Michael Schorpp and Mani Larijani and Thomas Boehm},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  pages={E3211 - E3220}
Significance Cytidine deaminases of the AID/APOBEC family mutate the genetic material of pathogens or contribute to the generation and diversification of antibody repertoires in jawed vertebrates. In the extant jawless vertebrate, the lamprey, two members of the AID/APOBEC family are implicated in the somatic diversification of variable lymphocyte receptor (VLR) repertoires. We discovered an unexpected diversity of cytidine deaminase genes within and among lamprey species. The cytidine… 

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