Expansion of the eukaryotic proteome by alternative splicing

@article{Nilsen2010ExpansionOT,
  title={Expansion of the eukaryotic proteome by alternative splicing},
  author={Timothy W Nilsen and Brenton R Graveley},
  journal={Nature},
  year={2010},
  volume={463},
  pages={457-463}
}
The collection of components required to carry out the intricate processes involved in generating and maintaining a living, breathing and, sometimes, thinking organism is staggeringly complex. Where do all of the parts come from? Early estimates stated that about 100,000 genes would be required to make up a mammal; however, the actual number is less than one-quarter of that, barely four times the number of genes in budding yeast. It is now clear that the 'missing' information is in large part… CONTINUE READING

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