Expansion of the classification of FTLD-TDP: distinct pathology associated with rapidly progressive frontotemporal degeneration

@article{Lee2017ExpansionOT,
  title={Expansion of the classification of FTLD-TDP: distinct pathology associated with rapidly progressive frontotemporal degeneration},
  author={Edward K. B. Lee and S{\'i}lvia Porta and G. Michael Baer and Yan Xu and Eunran Suh and Linda K. Kwong and L. B. Elman and Murray Grossman and Virginia M. Y. Lee and David John Irwin and Vivianna M. D. Van Deerlin and John Q. Trojanowski},
  journal={Acta Neuropathologica},
  year={2017},
  volume={134},
  pages={65-78}
}
Frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP) can typically be categorized into one of four distinct histopathologic patterns of TDP-43 pathology, types A to D. The strength of this histopathologic classification lies in the association between FTLD-TDP subtypes and various clinical and genetic features of disease. Seven cases of FTLD-TDP were identified here which were difficult to classify based on existing pathologic criteria. Distinct features common to these cases… CONTINUE READING
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