Expansion of regulatory CD8+ T-lymphocytes and fall of activated CD8+ T-lymphocytes after i.v. methyl-prednisolone for multiple sclerosis relapse.

@article{Aristimuo2008ExpansionOR,
  title={Expansion of regulatory CD8+ T-lymphocytes and fall of activated CD8+ T-lymphocytes after i.v. methyl-prednisolone for multiple sclerosis relapse.},
  author={Carol Aristimu{\~n}o and Joaqu{\'i}n Moya Navarro and Clara de Andr{\'e}s and Luisa Mart{\'i}nez-Gin{\'e}s and Santiago Gim{\'e}nez-Rold{\'a}n and E Fernandez-cruz and Silvia S{\'a}nchez-Ram{\'o}n},
  journal={Journal of neuroimmunology},
  year={2008},
  volume={204 1-2},
  pages={131-5}
}
INTRODUCTION Multiple sclerosis (MS) is a multifocal chronic inflammatory demyelinating disease of the central nervous system. Axonal damage correlates with the presence of macrophages and CD8+ T-lymphocytes at brain lesions. The gold standard of therapy at MS relapse are iv glucocorticoids (GC). The aim of the study was to assess the changes on the different subsets of circulating CD8+ T-lymphocytes at relapse and after iv GC therapy. PATIENTS AND METHODS We consecutively studied 20 patients… CONTINUE READING