Expansion of quasispecies diversity but no evidence for adaptive evolution of SHIV during rapid serial transfers among seronegative macaques.

@article{Balfe2004ExpansionOQ,
  title={Expansion of quasispecies diversity but no evidence for adaptive evolution of SHIV during rapid serial transfers among seronegative macaques.},
  author={Peter Balfe and Sarah J Shapiro and Mayla Hsu and Clarisa Buckner and Janet M. Harouse and Cecilia Cheng-Mayer},
  journal={Virology},
  year={2004},
  volume={318 1},
  pages={
          267-79
        }
}
Four successive, rapid serial passages of the nonpathogenic, CCR5-tropic simian-human immunodeficiency virus SHIV(SF162) in rhesus macaques resulted in an increase in acute plasma viremia with each passage and the emergence of a pathogenic isolate SHIV(SF162P3) in one of the passage three transfer animals (macaque T353). To explore the mechanism(s) underlying increased virulence of SHIV(SF162) upon in vivo passage, the evolution of the HIV-1 envelope gene was characterized in plasma and PBMC… CONTINUE READING
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