• DOI:10.1007/s00262-015-1737-x
Corpus ID: 24452149

Expansion of myeloid-derived suppressor cells in chronic obstructive pulmonary disease and lung cancer: potential link between inflammation and cancer

@article{Scrimini2015ExpansionOM,
  title={Expansion of myeloid-derived suppressor cells in chronic obstructive pulmonary disease and lung cancer: potential link between inflammation and cancer},
  author={Sergio Scrimini and J. Pons and A. Agusti and A. Clemente and Marta Cresp{\'i} Sall{\'a}n and Josep Miquel Bauç{\`a} and J. Soriano and B. Cosio and M. Lopez and C. Crespi and J. Sauleda},
  journal={Cancer Immunology, Immunotherapy},
  year={2015},
  volume={64},
  pages={1261-1270}
}

Sergio Scrimini, J. Pons, +8 authors J. Sauleda

Published 2015

Biology, Medicine

Cancer Immunology, Immunotherapy

AbstractBackground Chronic obstructive pulmonary disease (COPD) is a risk factor for lung cancer (LC). Myeloid-derived suppressor cells (MDSCs) down-regulate the T cell receptor ζ chain (TCR ζ) through l-arginine deprivation and lead to T cell dysfunction and deficient antitumor immunity. We hypothesized that abnormally high levels of MDSCs in COPD patients may alter tumor immunosurveillance.MethodsWe compared the proportion of circulating MDSCs (Lin-HLA-DR-/CD33+/CD11b+) (by flow cytometry… CONTINUE READING

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