Expansion of myeloid-derived suppressor cells in chronic obstructive pulmonary disease and lung cancer: potential link between inflammation and cancer

@article{Scrimini2015ExpansionOM,
  title={Expansion of myeloid-derived suppressor cells in chronic obstructive pulmonary disease and lung cancer: potential link between inflammation and cancer},
  author={Sergio Scrimini and J. Pons and A. Agusti and A. Clemente and Marta Cresp{\'i} Sall{\'a}n and Josep Miquel Bauç{\`a} and J. Soriano and B. Cosio and M. Lopez and C. Crespi and J. Sauleda},
  journal={Cancer Immunology, Immunotherapy},
  year={2015},
  volume={64},
  pages={1261-1270}
}
  • Sergio Scrimini, J. Pons, +8 authors J. Sauleda
  • Published 2015
  • Biology, Medicine
  • Cancer Immunology, Immunotherapy
  • AbstractBackground Chronic obstructive pulmonary disease (COPD) is a risk factor for lung cancer (LC). Myeloid-derived suppressor cells (MDSCs) down-regulate the T cell receptor ζ chain (TCR ζ) through l-arginine deprivation and lead to T cell dysfunction and deficient antitumor immunity. We hypothesized that abnormally high levels of MDSCs in COPD patients may alter tumor immunosurveillance.MethodsWe compared the proportion of circulating MDSCs (Lin-HLA-DR-/CD33+/CD11b+) (by flow cytometry… CONTINUE READING
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