Expansion of functional human mucosal-associated invariant T cells via reprogramming to pluripotency and redifferentiation.

Abstract

Mucosal-associated invariant T (MAIT) cells play an important physiological role in host pathogen defense and may also be involved in inflammatory disorders and multiple sclerosis. The rarity and inefficient expansion of these cells have hampered detailed analysis and application. Here, we report an induced pluripotent stem cell (iPSC)-based reprogramming… (More)
DOI: 10.1016/j.stem.2013.03.001

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