Expansion of effector memory TCR Vbeta4+ CD8+ T cells is associated with latent infection-mediated resistance to transplantation tolerance.

@article{Stapler2008ExpansionOE,
  title={Expansion of effector memory TCR Vbeta4+ CD8+ T cells is associated with latent infection-mediated resistance to transplantation tolerance.},
  author={Dale Stapler and Eun D. Han Lee and Saranya A. Selvaraj and Andrew G. Evans and Leslie S Kean and Samuel H Speck and Christian P Larsen and Shivaprakash Gangappa},
  journal={Journal of immunology},
  year={2008},
  volume={180 5},
  pages={3190-200}
}
Therapies that control largely T cell-dependent allograft rejection in humans also possess the undesirable effect of impairing T cell function, leaving transplant recipients susceptible to opportunistic viruses. Prime among these opportunists are the ubiquitous herpesviruses. To date, studies are lacking that address the effect of viruses that establish a true latent state on allograft tolerance or the effect of tolerance protocols on the immune control of latent viruses. By using a mixed… CONTINUE READING

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