Expansion of a subset of CD14highCD16negCCR2low/neg monocytes functionally similar to myeloid-derived suppressor cells during SIV and HIV infection.

@article{Gama2012ExpansionOA,
  title={Expansion of a subset of CD14highCD16negCCR2low/neg monocytes functionally similar to myeloid-derived suppressor cells during SIV and HIV infection.},
  author={Lucio Gama and Erin N. Shirk and Julia N. Russell and Karina In{\'a}cio Carvalho and Ming Li and Suzanne e. Queen and Jorge Agle Kalil and M. Christine Zink and Janice E. Clements and Esper George Kallas},
  journal={Journal of leukocyte biology},
  year={2012},
  volume={91 5},
  pages={803-16}
}
Monocytes have been categorized in three main subpopulations based on CD14 and CD16 surface expression. Classical monocytes express the CD14(++)CD16(-)CCR2(+) phenotype and migrate to inflammatory sites by quickly responding to CCL2 signaling. Here, we identified and characterized the expansion of a novel monocyte subset during HIV and SIV infection, which were undistinguishable from classical monocytes, based on CD14 and CD16 expression, but expressed significantly lower surface CCR2… CONTINUE READING