Expansion of a chromosomal repeat in Escherichia coli: roles of replication, repair, and recombination functions

@article{Poteete2008ExpansionOA,
  title={Expansion of a chromosomal repeat in Escherichia coli: roles of replication, repair, and recombination functions},
  author={Anthony R. Poteete},
  journal={BMC Molecular Biology},
  year={2008},
  volume={10},
  pages={14 - 14}
}
BackgroundPrevious studies of gene amplification in Escherichia coli have suggested that it occurs in two steps: duplication and expansion. Expansion is thought to result from homologous recombination between the repeated segments created by duplication. To explore the mechanism of expansion, a 7 kbp duplication in the chromosome containing a leaky mutant version of the lac operon was constructed, and its expansion into an amplified array was studied.ResultsUnder selection for lac function… CONTINUE READING
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