Expansion of Vgamma9 Vdelta2 T cells is triggered by Francisella tularensis-derived phosphoantigens in tularemia but not after tularemia vaccination.

@article{Poquet1998ExpansionOV,
  title={Expansion of Vgamma9 Vdelta2 T cells is triggered by Francisella tularensis-derived phosphoantigens in tularemia but not after tularemia vaccination.},
  author={Yannick Poquet and Michal Kroca and Franck Albert Halary and Stephan Stenmark and M A Peyrat and Marc Bonneville and Jean Jacques Fourni{\'e} and Anders Sj{\"o}stedt},
  journal={Infection and immunity},
  year={1998},
  volume={66 5},
  pages={2107-14}
}
Tularemia is a disease caused by the facultative intracellular bacterium Francisella tularensis. Here we demonstrate that during the first weeks of infection, a significant increase in levels of Vgamma9 Vdelta2 cells occurred in peripheral blood: in 13 patients analyzed 7 to 18 days after the onset of disease, these lymphocytes represented, on average, 30.5% of CD3+ cells and nearly 100% of gammadelta+ T cells. By contrast, after vaccination with the live vaccine strain (LVS) of F. tularensis… CONTINUE READING

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