Expansion of Tumor-Infiltrating CD8+ T cells Expressing PD-1 Improves the Efficacy of Adoptive T-cell Therapy.

@article{FernandezPoma2017ExpansionOT,
  title={Expansion of Tumor-Infiltrating CD8+ T cells Expressing PD-1 Improves the Efficacy of Adoptive T-cell Therapy.},
  author={Sarita M Fernandez-Poma and Diego Salas-Benito and Teresa Lozano and Noelia Casares and Jos{\'e}-Ignacio Riezu-Boj and Uxua Manche{\~n}o and Edurne Elizalde and Diego Alignani and Natalia Zubeldia and Itziar Otano and Enrique Conde and Pablo Sarobe and Juan J Lasarte and Sandra Herv{\'a}s-Stubbs},
  journal={Cancer research},
  year={2017},
  volume={77 13},
  pages={3672-3684}
}
Recent studies have found that tumor-infiltrating lymphocytes (TIL) expressing PD-1 can recognize autologous tumor cells, suggesting that cells derived from PD-1+ TILs can be used in adoptive T-cell therapy (ACT). However, no study thus far has evaluated the antitumor activity of PD-1-selected TILs in vivo In two mouse models of solid tumors, we show that PD-1 allows identification and isolation of tumor-specific TILs without previous knowledge of their antigen specificities. Importantly… CONTINUE READING