Expansion of EBNA1-specific effector T cells in posttransplantation lymphoproliferative disorders.

@article{Jones2010ExpansionOE,
  title={Expansion of EBNA1-specific effector T cells in posttransplantation lymphoproliferative disorders.},
  author={Kimberley A Jones and Jamie P. Nourse and Leanne Morrison and Do Nguyen-Van and Denis J. Moss and Scott R. Burrows and Maher K Gandhi},
  journal={Blood},
  year={2010},
  volume={116 13},
  pages={
          2245-52
        }
}
Immunosuppression resulting in impaired Epstein-Barr virus (EBV)-specific T-cell immunity is involved in the pathogenesis of EBV-positive post-transplantation lymphoproliferative disorder (EBV(+) PTLD). Restoration of EBV-specific T-cell immunity by adoptive immunotherapy can induce remission. EBV-nuclear antigen-1 (EBNA1) is unique in being expressed in all cases of EBV(+) PTLD. Recent data demonstrate that EBNA1 is not immunologically silent and can be exploited as a T-cell target. There are… CONTINUE READING
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Differential EXPANSION OF EBNA1-SPECIFIC T CELLS

  • A Leen, P Meij, I Redchenko
  • IN PTLD 2251 BLOOD,
  • 2010

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