Expansion of CD56-negative, CD16-positive, KIR-expressing natural killer cells after T cell-depleted haploidentical hematopoietic stem cell transplantation.

@article{Angelis2011ExpansionOC,
  title={Expansion of CD56-negative, CD16-positive, KIR-expressing natural killer cells after T cell-depleted haploidentical hematopoietic stem cell transplantation.},
  author={Claudia de Angelis and Antonella Mancusi and Loredana Ruggeri and Marusca Capanni and Elena Urbani and Andrea Velardi and Martin Stern},
  journal={Acta haematologica},
  year={2011},
  volume={126 1},
  pages={13-20}
}
The main functions of natural killer (NK) cells are early protection against viruses or tumor cells and production of cytokines that regulate immune functions. The present study assessed the role of different NK subsets in exerting graft-versus-leukemia effects in recipients of human leukocyte antigen (HLA) haploidentical hematopoietic transplants and monitored for the first time CD3-/CD56- lymphocyte expansion. CD3-/CD56- cells expressed NK cell-associated molecules, such as CD16, NKp46, NKp30… CONTINUE READING
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