Expansion of CD56- NK cells in chronic HCV/HIV-1 co-infection: reversion by antiviral treatment with pegylated IFNalpha and ribavirin.

@article{Gonzalez2008ExpansionOC,
  title={Expansion of CD56- NK cells in chronic HCV/HIV-1 co-infection: reversion by antiviral treatment with pegylated IFNalpha and ribavirin.},
  author={Veronica D. Gonzalez and Karolin Falconer and Jakob Micha{\"e}lsson and Markus Moll and Olle Reichard and Annette Alaeus and Johan K Sandberg},
  journal={Clinical immunology},
  year={2008},
  volume={128 1},
  pages={46-56}
}
Co-infection with HCV and HIV-1 is a problem of increasing importance and the role of innate cellular immunity in this co-infection is incompletely understood. Here, we have observed sharply elevated numbers of CD56(-)CD16(+) perforin(low) NK cells in HCV/HIV-1 co-infected subjects on antiretroviral therapy. Interestingly, this expansion of unconventional CD56(-) NK cells rapidly reverted when HCV was suppressed by IFNalpha and ribavirin treatment, and was not seen in mono-infected control… CONTINUE READING

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