Expansion of 2B4+ natural killer (NK) cells and decrease in NKp46+ NK cells in response to influenza.

@article{Jost2011ExpansionO2,
  title={Expansion of 2B4+ natural killer (NK) cells and decrease in NKp46+ NK cells in response to influenza.},
  author={S. D. Jost and Jeff Reardon and Eric Peterson and Danielle Poole and Ronald J. Bosch and Galit Alter and Marcus Altfeld},
  journal={Immunology},
  year={2011},
  volume={132 4},
  pages={516-26}
}
Several studies have highlighted the importance of murine natural killer (NK) cells in the control of influenza virus infection, notably through the natural cytotoxicity receptor NKp46. However, little is known about the involvement of NK cells in human influenza infection. Here, we show that upon in vitro exposure to influenza, NKp46 expression on NK cells decreases, whereas expression of 2B4, an activating receptor that can enhance natural cytotoxicity in synergy with NKp46, is up-regulated… CONTINUE READING

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