Expansion and long-range differentiation of the NKT cell lineage in mice expressing CD1d exclusively on cortical thymocytes

@article{Wei2005ExpansionAL,
  title={Expansion and long-range differentiation of the NKT cell lineage in mice expressing CD1d exclusively on cortical thymocytes},
  author={Datsen George Wei and Hyunji Lee and Se-Ho Park and Lucie Beaudoin and Luc Teyton and Agn{\`e}s Lehuen and Albert Bendelac},
  journal={The Journal of Experimental Medicine},
  year={2005},
  volume={202},
  pages={239 - 248}
}
Unlike conventional major histocompatibility complex-restricted T cells, Valpha14-Jalpha18 NKT cell lineage precursors engage in cognate interactions with CD 1 d-expressing bone marrow-derived cells that are both necessary and sufficient for their thymic selection and differentiation, but the nature and sequence of these interactions remain partially understood. After positive selection mediated by CD1d-expressing cortical thymocytes, the mature NKT cell lineage undergoes a series of changes… CONTINUE READING