Expansion and functions of myeloid-derived suppressor cells in the tumor microenvironment.


Myeloid derived suppressor cells (MDSCs) are a group of immature myeloid cells accumulated in most cancer patients and mouse tumor models. MDSCs suppress host immune response and concurrently promote tumor angiogenesis, thereby promote tumor growth and progression. In this review, we discuss recent progresses in expansion and activity of tumor MDSCs, and… (More)
DOI: 10.1016/j.canlet.2015.10.022