Expansion and differentiation of IgM+ B cells in the rainbow trout peritoneal cavity in response to different antigens.

@article{Castro2017ExpansionAD,
  title={Expansion and differentiation of IgM+ B cells in the rainbow trout peritoneal cavity in response to different antigens.},
  author={Rosario Magdalena Romero Castro and Beatriz Ab{\'o}s and Luc{\'i}a Gonz{\'a}lez and Aitor G. Granja and Carolina Tafalla},
  journal={Developmental and comparative immunology},
  year={2017},
  volume={70},
  pages={
          119-127
        }
}
To date, intraperitoneal (i.p.) injection seems to be the most effective vaccination route in aquaculture, as many i.p. administered fish vaccines are capable of conferring strong and long-lasting immune responses. Despite this, how peritoneal leukocytes are regulated upon antigen encounter has only been scarcely studied in fish. Although, in the past, myeloid cells were thought to be the main responders to peritoneal inflammation, a recent study revealed that IgM+ B cells are one of the main… CONTINUE READING

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