Expansion and contraction of HIV-specific CD4 T cells with short bursts of viremia, but physical loss of the majority of these cells with sustained viral replication.

@article{Seth2005ExpansionAC,
  title={Expansion and contraction of HIV-specific CD4 T cells with short bursts of viremia, but physical loss of the majority of these cells with sustained viral replication.},
  author={Nilufer P. Seth and Daniel A. Kaufmann and Timothy P. Lahey and E. S. Rosenberg and Kai W Wucherpfennig},
  journal={Journal of immunology},
  year={2005},
  volume={175 10},
  pages={
          6948-58
        }
}
Chronic infection with the HIV results in poor HIV-specific CD4 T cell proliferation, but more recent analyses using intracellular cytokine staining demonstrated that IFN-gamma-producing, HIV-specific CD4 T cells can be detected for years in HIV-infected subjects. Because it is not known whether the majority of HIV-specific T cells are lost or become dysfunctional, we examined the kinetics of the T cell response over an extended period of time using a panel of 10 HLA-DR tetramers loaded with… CONTINUE READING
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