Expansion and characterization of cancer stem-like cells in squamous cell carcinoma of the head and neck.

@article{Okamoto2009ExpansionAC,
  title={Expansion and characterization of cancer stem-like cells in squamous cell carcinoma of the head and neck.},
  author={A. Okamoto and K. Chikamatsu and K. Sakakura and K. Hatsushika and G. Takahashi and K. Masuyama},
  journal={Oral oncology},
  year={2009},
  volume={45 7},
  pages={
          633-9
        }
}
Evidence has accumulated indicating that only a minority of cancer cells with stem cell properties, cancer stem cells (CSCs), are responsible for maintenance and growth of the tumor. CD44 is currently used to identify CSCs as one of the cell surface markers for solid tumors. Here we report the identification, expansion, and characterization of CD44+ cancer stem-like cells from a permanent squamous cell carcinoma of the head and neck (SCCHN) cell line. Under serum-free medium culture conditions… Expand
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TLDR
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IMMUNOREGULATORY PROPERTIES OF CD 44 + CANCER STEM-LIKE CELLS IN SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK
Background—CD44 was found as a surface marker in cancer stem cell (CSC) of squamous cell carcinoma of the head and neck (SCCHN); however, the immunologic properties of such CSCs have not yet beenExpand
Cancer Stem-Like Cells on Tumorigenesis of Oral Squamous Cell Carcinoma
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These cancer stem-like cell properties in OSCC and other cancers should be warranted in the future translational oncology with the ultimate objective of improving anti-cancer therapy. Expand
Endothelial cell-initiated signaling promotes the survival and self-renewal of cancer stem cells.
TLDR
Findings indicate that endothelial cell-initiated signaling can enhance the survival and self-renewal of head and neck CSC. Expand
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