Expansion-Repression Mechanism for Scaling the Dpp Activation Gradient in Drosophila Wing Imaginal Discs

@article{BenZvi2011ExpansionRepressionMF,
  title={Expansion-Repression Mechanism for Scaling the Dpp Activation Gradient in Drosophila Wing Imaginal Discs},
  author={Danny Ben-Zvi and George Pyrowolakis and Naama Barkai and Ben-Zion Shilo},
  journal={Current Biology},
  year={2011},
  volume={21},
  pages={1391-1396}
}
Maintaining a proportionate body plan requires the adjustment or scaling of organ pattern with organ size. Scaling is a general property of developmental systems, yet little is known about its underlying molecular mechanisms. Using theoretical modeling, we examine how the Dpp activation gradient in the Drosophila wing imaginal disc scales with disc size. We predict that scaling is achieved through an expansion-repression mechanism [1] whose mediator is the widely diffusible protein Pentagone… CONTINUE READING

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