Expanding the roles for pregnane X receptor in cancer: proliferation and drug resistance in ovarian cancer.

@article{Gupta2008ExpandingTR,
  title={Expanding the roles for pregnane X receptor in cancer: proliferation and drug resistance in ovarian cancer.},
  author={Divya Gupta and Madhukumar Venkatesh and Hongwei Wang and Sean W Kim and Michael W. Sinz and Gary L. Goldberg and Kathleen A Whitney and Clifford B. Longley and Sridhar Mani},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2008},
  volume={14 17},
  pages={5332-40}
}
PURPOSE We examined the presence of the pregnane X receptor (PXR) and its effects on ovarian cancer cells after activation by its cognate ligand. EXPERIMENTAL DESIGN SKOV-3 and OVCAR-8 ovarian carcinoma cells were analyzed for expression of PXR by quantitative reverse transcription-PCR and Western blot. Human ovarian cancer tissue was also analyzed for PXR expression by immunochemistry. Ligand (agonist)-induced PXR target genes were analyzed in SKOV-3 cells by quantitative reverse… CONTINUE READING