Expanding the number of 'druggable' targets: non-enzymes and protein-protein interactions.


Following sequencing and assembly of the human genome, the preferred methods for identification of new drug targets have changed dramatically. Modern tactics such as genome-wide association studies (GWAS) and deep sequencing are fundamentally different from the pharmacology-guided approaches used previously, in which knowledge of small molecule ligands… (More)
DOI: 10.1111/cbdd.12066


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