Expanding the computational toolbox for mining cancer genomes

@article{Ding2014ExpandingTC,
  title={Expanding the computational toolbox for mining cancer genomes},
  author={Li Ding and Michael C. Wendl and Joshua F. McMichael and Benjamin J. Raphael},
  journal={Nature Reviews Genetics},
  year={2014},
  volume={15},
  pages={556-570}
}
High-throughput DNA sequencing has revolutionized the study of cancer genomics with numerous discoveries that are relevant to cancer diagnosis and treatment. The latest sequencing and analysis methods have successfully identified somatic alterations, including single-nucleotide variants, insertions and deletions, copy-number aberrations, structural variants and gene fusions. Additional computational techniques have proved useful for defining the mutations, genes and molecular networks that… CONTINUE READING

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