Expanding multimodal microscopy by high spectral resolution coherent anti-Stokes Raman scattering imaging for clinical disease diagnostics.

@article{Meyer2013ExpandingMM,
  title={Expanding multimodal microscopy by high spectral resolution coherent anti-Stokes Raman scattering imaging for clinical disease diagnostics.},
  author={Tobias Meyer and Mario Chemnitz and Martin Baumgartl and Thomas Gottschall and Torbj{\"o}rn Pascher and Christian Matth{\"a}us and Bernd F. M. Romeike and Bernhard R Brehm and Jens Limpert and Andreas T{\"u}nnermann and Michael Schmitt and Benjamin Dietzek and J{\"u}rgen Popp},
  journal={Analytical chemistry},
  year={2013},
  volume={85 14},
  pages={6703-15}
}
Over the past years fast label-free nonlinear imaging modalities providing molecular contrast of endogenous disease markers with subcellular spatial resolution have been emerged. However, applications of these imaging modalities in clinical settings are still at the very beginning. This is because single nonlinear imaging modalities such as second-harmonic generation (SHG) and two-photon excited fluorescence (TPEF) have only limited value for diagnosing diseases due to the small number of… CONTINUE READING