Expanding members and roles of the calpain superfamily and their genetically modified animals.

@article{Sorimachi2010ExpandingMA,
  title={Expanding members and roles of the calpain superfamily and their genetically modified animals.},
  author={H. Sorimachi and S. Hata and Y. Ono},
  journal={Experimental animals},
  year={2010},
  volume={59 5},
  pages={
          549-66
        }
}
Calpains are intracellular Ca²(+)-dependent cysteine proteases (Clan CA, family C02, EC 3.4.22.17) found in almost all eukaryotes and some bacteria. Calpains display limited proteolytic activity at neutral pH, proteolysing substrates to transform and modulate their structures and activities, and are therefore called "modulator proteases". The human genome has 15 genes that encode a calpain-like protease domain, generating diverse calpain homologues that possess combinations of several… Expand
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