Expanding fields of genetically altered cells in head and neck squamous carcinogenesis.

@article{Braakhuis2005ExpandingFO,
  title={Expanding fields of genetically altered cells in head and neck squamous carcinogenesis.},
  author={Boudewijn J. M. Braakhuis and C. Rene ¤ Leemans and Ruud H. Brakenhoff},
  journal={Seminars in cancer biology},
  year={2005},
  volume={15 2},
  pages={113-20}
}
Recent molecular pathology studies in head and neck cancer support a carcinogenesis model in which the development of a field with genetically altered cells plays a central role. This preneoplastic field is of monoclonal origin and expands non-invasively superseding normal epithelium. Clonal divergence and selection within the field ultimately leads to the development of cancer. These fields can be large (over 7 cm diameter) and are often not visible for the surgeon explaining that they may… CONTINUE READING

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