Expanding ester biosynthesis in Escherichia coli.

@article{Rodriguez2014ExpandingEB,
  title={Expanding ester biosynthesis in Escherichia coli.},
  author={Gabriel M. Rodriguez and Yohei Tashiro and Shota Atsumi},
  journal={Nature chemical biology},
  year={2014},
  volume={10 4},
  pages={259-65}
}
To expand the capabilities of whole-cell biocatalysis, we have engineered Escherichia coli to produce various esters. The alcohol O-acyltransferase (ATF) class of enzyme uses acyl-CoA units for ester formation. The release of free CoA upon esterification with an alcohol provides the free energy to facilitate ester formation. The diversity of CoA molecules found in nature in combination with various alcohol biosynthetic pathways allows for the biosynthesis of a multitude of esters. Small to… CONTINUE READING
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