Expanding discriminative dimensions for analysis and imaging† †This article is dedicated to Prof. Manfred Eigen. ‡ ‡Electronic supplementary information (ESI) available: Reduction of photo-(physical)chemical mechanisms to a two-state exchange, kinetic analysis of the two-state model, retrieval of concentrations from the observables, improvement of the spatial resolution. See DOI: 10.1039/c4sc03955f Click here for additional data file.