• Corpus ID: 211010828

Expanding bacterial colonies and growing tissues behave as soft driven glasses

@article{Tjhung2020ExpandingBC,
  title={Expanding bacterial colonies and growing tissues behave as soft driven glasses},
  author={Elsen Tjhung and Ludovic Berthier},
  journal={arXiv: Statistical Mechanics},
  year={2020}
}
We develop a minimal model to describe growing dense active matter such as biological tissues, bacterial colonies and biofilms, that are driven by a competition between particle division and steric repulsion. We provide a detailed numerical analysis of collective and single particle dynamics. We show that the microscopic dynamics can be understood as the superposition of an affine radial component due to the global growth, and of a more complex non-affine component which displays features… 

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References

SHOWING 1-10 OF 74 REFERENCES

Geometry and Mechanics of Microdomains in Growing Bacterial Colonies

This work investigates the geometrical and mechanical properties of a bacterial colony growing on a substrate with free boundary, and demonstrates that such an expanding colony self-organizes into a "mosaic" of micro-domains consisting of highly aligned cells.

Biomechanical ordering of dense cell populations

A continuum model of collective cell dynamics based on equations for local cell density, velocity, and the tensor order parameter is developed and used to elucidate the mechanism of cell ordering and quantify the relationship between the dynamics of cell proliferation and the spatial structure of the population.

Discontinuous fluidization transition in time-correlated assemblies of actively deforming particles.

This work considers a microscopic model of "actively deforming" particles where local fluctuations of the particle size constitute a unique source of motion and demonstrates that collective motion can emerge under the sole influence of such active volume fluctuations.

Motility-driven glass and jamming transitions in biological tissues.

A self-propelled Voronoi (SPV) model is studied that simultaneously captures polarized cell motility and multi-body cell-cell interactions in a confluent tissue, where there are no gaps between cells, and precisely captures a jamming transition from a solid-like state to a fluid- like state.

Cell growth rate dictates the onset of glass to fluid-like transition and long time super-diffusion in an evolving cell colony

The findings for the collective migration, which also suggests that tumor evolution occurs in a polarized manner, are in quantitative agreement with in vitro experiments and establish the universality of super-diffusion in a class of seemingly unrelated non-equilibrium systems.

A growing bacterial colony in two dimensions as an active nematic

The authors find that a growing bacterial colony harbours internal cellular flows affecting orientational ordering in its interior and at the boundary, and suggest this system may belong to a new active matter universality class.

Highly nonlinear dynamics in a slowly sedimenting colloidal gel.

It is found that the microscopic dynamics exhibit remarkable scaling properties when time is normalized by the strain rate, showing that the gel microscopic restructuring is dominated by its macroscopic deformation.

Universal motion patterns in confluent cell monolayers

Epithelial cell monolayers show remarkable long-range displacement and velocity correlations reminiscent of supercooled liquids and active nematics. Here we show that many of the observed features

Self-Driven Jamming in Growing Microbial Populations

The results suggest that self-driven jamming and build-up of large mechanical pressures is a natural tendency of microbes growing in confined spaces, contributing to microbial pathogenesis and biofouling.

Superdiffusive, heterogeneous, and collective particle motion near the jamming transition in athermal disordered materials

We use computer simulations to study the microscopic dynamics of an athermal assembly of soft particles near the fluid-to-solid, jamming transition. Borrowing tools developed to study dynamic
...