Expanding antigen-specific regulatory networks to treat autoimmunity

@article{ClementeCasares2016ExpandingAR,
  title={Expanding antigen-specific regulatory networks to treat autoimmunity},
  author={Xavier Clemente-Casares and Jes{\'u}s Blanco and Poornima Ambalavanan and Jun Yamanouchi and Santiswarup Singha and C{\'e}sar Fandos and Sue Jean Tsai and Jinguo Wang and Nahir Garabatos and Cristina Izquierdo and Smriti Agrawal and Michael B Keough and V. Wee Yong and Eddie James and Anna Moore and Yang Yang and Thomas Stratmann and Pau Serra and Pere Santamaria},
  journal={Nature},
  year={2016},
  volume={530},
  pages={434-440}
}
Regulatory T cells hold promise as targets for therapeutic intervention in autoimmunity, but approaches capable of expanding antigen-specific regulatory T cells in vivo are currently not available. Here we show that systemic delivery of nanoparticles coated with autoimmune-disease-relevant peptides bound to major histocompatibility complex class II (pMHCII) molecules triggers the generation and expansion of antigen-specific regulatory CD4+ T cell type 1 (TR1)-like cells in different mouse… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 96 times over the past 90 days. VIEW TWEETS
41 Citations
29 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 41 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 29 references

Safety and Efficacy of Antigen-Specific Regulatory T-Cell Therapy for Patients With Refractory Crohn's Disease

  • P Desreumaux
  • Gastroenterology 143,
  • 2012

regulatory T-cell therapy is a safe and well-tolerated potential approach for treating refractory Crohn's disease

  • McLarnon, A. IBD
  • Nature Rev. Gastroenterol. Hepatol. 9, 559
  • 2012

Similar Papers

Loading similar papers…