Expanding antigen-specific regulatory networks to treat autoimmunity

  title={Expanding antigen-specific regulatory networks to treat autoimmunity},
  author={Xavier Clemente-Casares and Jes{\'u}s Blanco and Poornima Ambalavanan and Jun Yamanouchi and Santiswarup Singha and C{\'e}sar Fandos and Sue Jean Tsai and Jinguo Wang and Nahir Garabatos and Cristina Izquierdo and Smriti Agrawal and Michael B Keough and V. Wee Yong and Eddie James and Anna Moore and Yang Yang and Thomas Stratmann and Pau Serra and Pere Santamaria},
Regulatory T cells hold promise as targets for therapeutic intervention in autoimmunity, but approaches capable of expanding antigen-specific regulatory T cells in vivo are currently not available. Here we show that systemic delivery of nanoparticles coated with autoimmune-disease-relevant peptides bound to major histocompatibility complex class II (pMHCII) molecules triggers the generation and expansion of antigen-specific regulatory CD4+ T cell type 1 (TR1)-like cells in different mouse… CONTINUE READING
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